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A new way of preventing Alzheimer's through olive-pomace oil

A new way of preventing Alzheimer's through olive-pomace oil

2018/20/11 - The Higher Council for Scientific Research (CSIC) and the Olive Pomace Oil Interprofessional (Oriva) have opened a new pathway for the prevention of Alzheimer's through a diet enriched with olive-pomace oil.

This is one of the main conclusions of the study "Protection against Alzheimer's disease by attenuating the activation of microglia by olive-pomace oil" carried out by the CSIC, with Dr. Javier Sánchez Perona as the principal investigator and whose presentation took place yesterday at the headquarters of the Spanish Ministry of Agriculture, Fisheries and Food (MAPA) in Madrid.

As detailed by Oriva, Alzheimer, whose cause is still unknown, is a neurodegenerative disease characterized by neuroinflammation that is related to the over-activation of microglia, a group of cells of the central nervous system whose main function is defensive. In this line, the research has explored the potential of olive-pomace oil to counteract the inflammation of microglia.

After 18 months of trials, the starting hypothesis has been confirmed, concluding that the bioactive compounds of olive-pomace oil -oleanolic acid, α-tocopherol and β-sitosterol- may have a protective effect against Alzheimer's by attenuating the activation of the microglia.

"The different concentrations of minor components of olive-pomace oil have reduced the markers of neuronal inflammation. In some cases, the compounds have nullified and even reversed these markers," has explained Sánchez Perona.

In the first phase of the study, in which cells have been stimulated with lipoposaccharide (LPS), the reduction of markers of inflammation in microglia has been between 50% and 95%. In the second phase of the study, in which the cells have been stimulated with triglyceride-rich lipoproteins (TRL), the reduction has been even more significant, reaching between 100 and 185%.

An unpublished hypothesis
Sánchez Perona stressed that "the research developed for Oriva represents a new milestone in demonstrating an unpublished research hypothesis so far. The main thing is that we have found that the transport of fat in the diet can contribute to the development of the disease. Therefore, we can take advantage of these lipoproteins as a Trojan horse to supply the brain with compounds with anti-inflammatory activity."

To continue advancing in this line, the study will continue with the second planned stage consisting of clinical trials to demonstrate if these effects are replicable in humans.

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